Organometallic cis‐Dichlorido Ruthenium(II) Ammine Complexes

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Bifunctional neutral half‐sandwich RuII complexes of the type [(η6‐arene)Ru(NH3)Cl2] where arene is p‐cym (1) or bip (2) were synthesised by the reaction of N,N‐dimethylbenzylamine (dmba), NH4PF6 and the corresponding RuII arene dimer, and were fully characterised. X‐ray crystallographic studies of [(η6‐p‐cym)Ru(NH3)Cl2]·{(dmba–H)(PF6)} (1a) and [(η6‐bip)Ru(NH3)Cl2] (2) show extensive H‐bond interactions in the solid state, mainly involving the NH3 and the Cl ligands, as well as weak aromatic stacking interactions. The half‐lives for the sequential hydrolysis of 1 and 2 determined by UV/Vis spectroscopy at 310 K ranged from a few minutes for the first aquation to ca. 45 min for the second aquation; the diaqua adducts were the predominant species at equilibrium. Arene loss during the aquation of complex 2 was observed. Upon hydrolysis, both complexes readily formed mono‐ and di‐9‐ethylguanine (9‐EtG) adducts in aqueous solution at 310 K. The reaction reached equilibrium after ca. 1.8 h in the case of complex 1 and was slower but more complete for complex 2 (before the onset of arene loss at ca. 2.7 h). Complexes 1 and 2 were not cytotoxic towards A2780 human ovarian cancer cells up to the maximum concentration tested (100 μM).

This publication has 69 references indexed in Scilit: