2‐Azidoethane‐1‐sulfonylfluoride (ASF): A Versatile Bis‐clickable Reagent for SuFEx and CuAAC Click Reactions
Authors:
- 25 January 2019
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2019 (8) , 1763-1769
Abstract
A new reagent, 2‐azidoethane‐1‐sulfonylfluoride (ASF), was synthesized from 2‐chloroethane‐1‐sulfonyl fluoride in 50g‐scale with 87 % yield. This novel reagent possesses two selectively clickable functionalities to be used for both CuAAC and SuFEx click reactions. The application of this reagent ASF to the construction of a class of novel 1,2,3‐triazole derived S(VI)‐F analogs was achieved in a quick, efficient and atom‐economical manner. Orthogonally clickable construction of a new class of dendrimers was also accomplished.Keywords
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