Radiographic quantifications of joint space narrowing progression by computer-based approach using temporal subtraction in rheumatoid wrist

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Abstract
Objective:To investigate the validity of a computer-based method using temporal subtraction in carpal joints of patients with rheumatoid arthritis (RA), which can detect the difference in joint space between two images with the joint space difference index (JSDI).Methods:The study consisted of 43 patients with RA (39 females and 4 males) who underwent radiography at baseline and at 1-year follow-up. The joint space narrowing (JSN) of carpal joints on bilateral hand radiographs was assessed by our computer-based method, using the Sharp/van der Heijde method as the standard of reference. We compared the JSDI of joints with JSN progression in the follow-up period with that of those without JSN progression. In addition, we examined whether there is a significant difference in JSDI in terms of laterality or topology of the joint.Results:The JSDI of joints with JSN progression was significantly higher than that of those without JSN progression (Mann–Whitney U test, p < 0.001). There was no statistically signifi...

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