Local spinal cord blood flow in experimental traumatic myelopathy

Authors:
  • AKArthur I. Kobrine
    Arthur I. Kobrine
  • TDThomas F. Doyle
    Thomas F. Doyle
  • AMAlbert N. Martins
    Albert N. Martins
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Abstract
✓ Focal blood flow was measured in the lateral funiculus and center of the spinal cord in the rhesus monkey both before and after a 600 gm-cm injury at T-10. Measurements made by the hydrogen clearance technique showed that blood flow in the lateral funiculus more than doubled within 4 hours after injury, returned to normal by 8 hours, and remained in the normal range for 24 hours. At no time was a hypoperfusion in the lateral funiculus present. Blood flow in the center of the spinal cord, at the level of the lesion, began to fall within 1 hour following injury and continued to fall for 4 hours. These data challenge the notion that spreading ischemia of the white matter is an important factor in the pathophysiology of experimental spinal cord injury.

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