SOLID DISPERSION OF ETHYL P-METHOXYCINNAMATE (EPMC) FROM KAEMPFERIA GALANGA RHIZOME BY FREEZE-DRYING METHOD

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Abstract
Objective: To increase the dissolution rate of Ethyl p-methoxycinnamate (EPMC), which was isolated from Kaempferia galanga rhizome, this study aimed to prepare and characterize a Solid Dispersion (SD) system using the hydrophilic polymer Hydroxypropyl Methylcellulose (HPMC) K4M. Methods: EPMC was isolated from the rhizome of Kaempferia galanga and identified using a melting point instrument (Differential Scanning Calorimetry) and Thin Layer Chromatography (TLC). Three distinct EPMC and HPMC K4M ratios-1:1, 1:2, and 1:3 (w/w)-were freeze-dried to prepare the SD. Fourier Transform Infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM), Powder X-ray Diffraction (PXRD), and Differential Scanning Calorimetry (DSC) were used to characterize the SD. For 60 min, the dissolution test was carried out in distilled water free of CO2 and with an extra 0.1% Sodium Lauryl Sulfate (SLS). Results: The characterization of SD systems showed a decrease in the endothermic peak and melting point in the DSC analysis, decreased peak intensity in the PXRD patterns, unchanged chemical structure in FT-IR analysis, and pores formation on the surface in SEM analysis. A significant increase in dissolution rate (p<0.05) was observed, with a 3.63-fold improvement for the 1:3 SD (60.603±1.163%) compared to intact EPMC (16.684±1.352%). Conclusion: The SD of EPMC-HPMC K4M was successfully formed, and a higher dissolution rate was achieved than that of the intact EPMC.

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