Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes

Authors:
  • XDXia Deng
    Xia Deng
  • LZLi Zhao
    Li Zhao
  • LYLing Yang
    Ling Yang
  • DWDong Wang
    Dong Wang
  • YLYanyan Li
    Yanyan Li
  • HXHong Xia
    Hong Xia
  • CWChenxi Wang
    Chenxi Wang
  • ZCZhensheng Cai
    Zhensheng Cai
  • LLLian Li
    Lian Li
  • ZZZhicong Zhao
    Zhicong Zhao
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Abstract
Aim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed. Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay. Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=− 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001]. Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.

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