Diabetes, Weight Change, and Pancreatic Cancer Risk

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Abstract
Pancreatic cancer is the third-leading cause of cancer-related death in the United States, with a 5-year survival rate of less than 10%.1 This low survival rate is largely associated with the diagnosis occurring at an advanced stage when the cancer is no longer curable. To date, patients with a strong family history or genetic predisposition and those with pancreatic cystic lesions have been the primary focus of pancreatic cancer early detection programs, with initial evidence indicating a shift to earlier stage disease and longer survival among those who undergo surveillance imaging.2,3 Nevertheless, these patients represent only 15% to 20% of those presenting with pancreatic cancer,4 and the US Preventive Services Task Force recommends against pancreatic cancer screening for asymptomatic individuals with average risk.5 The identification of other high-risk groups is necessary to enhance screening efforts.

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