Time to Benefit of Bisphosphonate Therapy for the Prevention of Fractures Among Postmenopausal Women With Osteoporosis

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Abstract
Osteoporosis is common among older women and is associated with approximately 1.9 million fractures every year in the US, at an estimated annual cost of $57 billion.1 Fractures among those with osteoporosis have been associated with increased functional impairment,2 reduced quality of life,3 and increased risk of mortality.4 Despite its clinical importance, osteoporosis is often underdiagnosed and undertreated, even among patients who have already experienced a hip fracture.5,6 Patterns in hip fracture rates over time suggest that this treatment gap is worsening, in part because of concerns about rare but serious adverse effects.7-9

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