KEAP1Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes
Open Access
- 31 March 2015
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 21 (7) , 1591-1601
Abstract
Purpose: Defective oxidative stress response may increase cancer susceptibility. In tumors, these rescue mechanisms may cause chemo- and radioresistance impacting patient outcome. We previously showed that genetic variation in the nuclear factor erythroid 2–related factor 2 (NFE2L2) is associated with breast cancer risk and prognosis. Here we further studied this pathway by investigating Kelch-like ECH-associated protein 1 (KEAP1).Keywords
All Related Versions
This publication has 43 references indexed in Scilit:
- Integrated molecular analysis of clear-cell renal cell carcinomaNature Genetics, 2013
- Comprehensive molecular portraits of human breast tumoursNature, 2012
- Comprehensive genomic characterization of squamous cell lung cancersNature, 2012
- Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 ProteinJournal of Biological Chemistry, 2012
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 SignalingCancer Cell, 2011
- Oxidative stress, inflammation, and cancer: How are they linked?Free Radical Biology and Medicine, 2010
- Inhibition of estrogen signaling activates the NRF2 pathway in breast cancerBreast Cancer Research and Treatment, 2010
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant ResponseMolecular Cell, 2009
- Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungsFree Radical Biology and Medicine, 2009
- Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signalingThe EMBO Journal, 2006