Temperature-sensitive mutant of avian erythroblastosis virus suggests a block of differentiation as mechanism of leukaemogenesis

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Abstract
A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 °C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 °C, haemoglobin synthesis can be induced by a shift to 41 °C. This indicates that the continuous expression of a viral gene product is necessary to maintain the undifferentiated state of the virus-transformed leukaemia cells.

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