CHEMICAL STRUCTURE OF JORO SPIDER TOXIN (JSTX)
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Open Access
- 1 January 1987
- journal article
- research article
- Published by Biomedical Research Press in Biomedical Research
- Vol. 8 (4) , 241-245
Abstract
Toxic principles obtained from the venom of Joro spider (Nephila ciavata) were purified with the reversed phase high performance liquid chromatography and four kinds of the major toxins (JSTX-l,-2,-3 and-4) were isolated. These principles commonly possessed 2,4-dihydroxyphenylacetyl-asparaginyl-cadaveryl moiety in the molecule. The structure of JSTX-3 was determined to be N-(2,4-dihydroxyphenylacetyl-L-asparaginyl)-N5[N-[4-[(3-aminopropyl)amino]butyl],6-alanyl]cadaverine. The structure activity relationship of the spider toxin was discussed.Keywords
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