Exclusion of Usher syndrome gene from much of chromosome 4
Authors:
- J.D. HolcombJHJ.D. Holcomb
- S.P. DaigerSDS.P. Daiger
- C.T. CaskeyCCC.T. Caskey
- M.Z. PeliasMPM.Z. Pelias
- B.R. AlfordBAB.R. Alford
- D.D. FontenotDFD.D. Fontenot
- J.F. HejtmancikJHJ.F. Hejtmancik
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 50 (2-3) , 102-106
Abstract
Usher syndrome is an autosomal recessive disease characterized by dual sensory impairments; affected individuals are born with a sensorineural hearing loss and ultimately lose their sight as retinitis pigmentosa develops. Conventional protein markers previously tested in a Louisiana Acadian kindred suggested tentative linkage to vitamin D-binding protein on chromosome 4. DNA linkage studies do not confirm this linkage relationship and exclude much of chromosome 4 as the site of the Usher syndrome gene in these families.Keywords
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