Behavior of silica particles introduced into an isolated rat heart as potential drug carriers
Authors:
- B BorakBBB Borak
- J ArkowskiJAJ Arkowski
- M SkrzypiecMSM Skrzypiec
- P ZiółkowskiPZP Ziółkowski
- B KrajewskaBKB Krajewska
- M WawrzyńskaMWM Wawrzyńska
- B GrotthusBGB Grotthus
- H GliniakHGH Gliniak
- A SzelagASA Szelag
- W MazurekWMW Mazurek
- D BiałyDBD Biały
- K MaruszewskiKMK Maruszewski
- 24 September 2007
- journal article
- Published by IOP Publishing in Biomedical Materials
- Vol. 2 (4) , 220-223
Abstract
Silica powders consisting of small spherical particles (50-200 nm) have been obtained by the sol-gel method. A suspension of such particles in the Krebs-Hanseleit solution has been introduced into the coronary circulation of a beating perfused rat heart. The influence of the suspension on the heart muscle and the coronary vessels in the rat body has been histopathologically examined. The particles have not left the lumen of the vessels and have not caused any side effects. These observations suggest the possibility of using such silica particles as a carrier for selected drugs.Keywords
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