Solid-Phase Synthesis of 3,4-Dihydro-1H-pyrimidine-2-ones Using Sodium Benzenesulfinate as a Traceless Linker
Authors:
- 7 July 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Combinatorial Chemistry
- Vol. 7 (5) , 721-725
Abstract
The facile preparation of 3,4-dihydropyrimidine-2-one derivatives with traceless solid-phase sulfone linker strategy is described. Key steps involved in the solid-phase synthetic procedure include (i) sulfinate acidification, (ii) condensation of urea or thiourea with aldehydes and sulfinic acid, and (iii) traceless product release via a one-pot cyclization−dehydration process. A library of 18 compounds was synthesized.Keywords
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