A Mild and Efficient Method for Copper-Catalyzed Ullmann-Type N-Arylation of Aliphatic Amines and Amino Acids

Authors:
  • YJYuyang Jiang
    Yuyang Jiang
  • HFHua Fu
    Hua Fu
  • QJQun Jiang
    Qun Jiang
  • DJDeshou Jiang
    Deshou Jiang
  • YZYufen Zhao
    Yufen Zhao
Publisher website
Google Scholar
Abstract
An efficient and general protocol for copper-catalyzed N-arylation of aliphatic amines and amino acids has been developed using aryl iodides under mild conditions (coupling temperature at 25-35 °C). For the N-(o-nitrophenyl) amino acid derivatives, ­subsequent reduction of the nitro group in the presence of tin(II) chloride resulted in 3,4-dihydroquinoxalin-2(1H)-one derivatives in good yields.