Doxorubicin-loaded DNA origami nanostructures: stability in vitreous and their uptake and toxicity in ocular cells
Open Access
- 27 August 2024
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Nanoscale
- Vol. 16 (37) , 17585-17598
Abstract
Doxorubicin-loaded DNA origami required additional Mg2+ to be stable in cell medium and vitreous at 37 °C. In retinal epithelial cells (ARPE-19), they were well-tolerated, but limited in their uptake.Keywords
Funding Information
- Joint Programming Initiative on Antimicrobial Resistance
- Research Council of Finland (323669)
- Suomen Kulttuurirahasto
- H2020 European Research Council (101001016)
- Emil Aaltosen Säätiö
- Sigrid Juséliuksen Säätiö
- Jane ja Aatos Erkon Säätiö
This publication has 93 references indexed in Scilit:
- DNA origami: a quantum leap for self-assembly of complex structuresChemical Society Reviews, 2011
- A primer to scaffolded DNA origamiNature Methods, 2011
- In Vitro Evaluation of a Targeted and Sustained Release System for Retinoblastoma Cells Using Doxorubicin as a Model DrugJournal of Ocular Pharmacology and Therapeutics, 2010
- Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origamiNature Nanotechnology, 2009
- Rapid prototyping of 3D DNA-origami shapes with caDNAnoNucleic Acids Research, 2009
- Self-assembly of DNA into nanoscale three-dimensional shapesNature, 2009
- Determination of doxorubicin in rabbit ocular tissues and pharmacokinetics after intravitreal injection of a single dose of doxorubicin-loaded poly-β-hydroxybutyrate microspheresJournal of Pharmaceutical and Biomedical Analysis, 2007
- Folding DNA to create nanoscale shapes and patternsNature, 2006
- Vitreous: A Barrier to Nonviral Ocular Gene TherapyInvestigative Ophthalmology & Visual Science, 2005
- Cardiotoxicity of Chemotherapeutic AgentsDrug Safety, 2000