Biotransformation of Flurbiprofen byCunninghamellaSpecies
Authors:
- 15 September 2010
- journal article
- research article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 76 (18) , 6299-6303
Abstract
The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated inCunninghamellaspp. Mono- and dihydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4′-hydroxyflurbiprofen was isolated by preparative high-pressure liquid chromatography (HPLC).Cunninghamella elegansDSM 1908 andC. blakesleeanaDSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.Keywords
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