The pcd Gene Encoding Piperideine-6-Carboxylate Dehydrogenase Involved in Biosynthesis of α-Aminoadipic Acid Is Located in the Cephamycin Cluster of Streptomyces clavuligerus
Authors:
- 1 September 1998
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 180 (17) , 4753-4756
Abstract
Three open reading frames (ORFs) have been located downstream of cefE in the cephamycin C gene cluster of Streptomyces clavuligerus . ORF13 ( pcd ) encodes a 496-amino-acid protein (molecular weight [MW], 52,488) with an N-terminal amino acid sequence identical to that of pure piperideine-6-carboxylate dehydrogenase. ORF14 ( cmcT ) encodes a 523-amino-acid protein (MW, 54,232) analogous to Streptomyces proteins for efflux and resistance to antibiotics. ORF15 ( pbp74 ) encodes a high molecular weight penicillin-binding protein (MW, 74,094).Keywords
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