Adaptation to periodic high-altitude hypoxia inhibits baroreflex vagal bradycardia in rats
- 1 April 2000
- journal article
- general pathology-and-pathological-physiology
- Published by Springer Nature in Bulletin of Experimental Biology and Medicine
- Vol. 129 (4) , 327-329
Abstract
A 3-week course of adaptation to high-altitude hypoxia (4500 m above sea level) inhibited baroreflex avagal bradycardia induced by a rapid rise of systemic blood pressure in conscious rats. Bradycardic responses to electrical stimulation of peripheral end of the right vagus nerve and methacholine (M2 muscarinic receptor agonist) in hypoxia-adapted rats did not differ from the control. It is concluded that hypoxia inhibits baroreflex vagal bradycardia by acting on a central element of the baroreceptor reflex archKeywords
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