Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
Open Access
- 9 August 2021
- journal article
- editorial
- Published by Springer Nature in Nature Communications
- Vol. 12 (1) , 1-4
Abstract
The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.Keywords
Funding Information
- Westlake Education Foundation Westlake Laboratory of Life Sciences and Biomedicine
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