Molecular characteristics of lung adenocarcinoma with respect to patient age at diagnosis

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Abstract
Lung cancer is primarily a disease of the elderly, with a median age at diagnosis around 70 years. In our study we sought to address the question of whether and how clinical characteristics, molecular alterations and molecular phenotypes differ between patient populations with early‐stage lung adenocarcinoma (AC) with respect to age at diagnosis. Patients were stratified based on age at diagnosis into five systematic age bins (EGFR and ALK) were confirmed. We also found an association between age at diagnosis and certain mutational signatures. However, age did not seem to drive transcriptional, copy number, or epigenetic variation in the tumors. Based on our findings, age at diagnosis alone does not appear to provide an additional layer of biological complexity above that of proposed genetic and transcriptional phenotypes of AC.
Funding Information
  • Cancerfonden (CAN 2018/685)
  • Fru Berta Kamprads Stiftelse (FBKS 2020‐15, FBKS 2021‐13)
  • Magnus Bergvalls Stiftelse (2021‐04321)
  • Sjöbergstiftelsen (Award 2019, Award 2022)

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