Reaction of S-nitrosothiols with ascorbate: clear evidence of two reactions

Author:
  • AHAnthony J. Holmes
    Anthony J. Holmes
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Abstract
Ascorbate reacts with S-nitrosothiols at pH 7.4 via two pathways, in which ascorbate (at low concentration) acts as a reducing agent generating CuI, and (at high concentration) acts as a nucleophile, attacking the nitroso group.