Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins

Authors:

VTVolodymyr P. Tryndyak
Volodymyr P. Tryndyak
OKOlga Kovalchuk
Olga Kovalchuk
IPIgor P. Pogribny
Igor P. Pogribny

16 January 2006

journal article
Published by Taylor & Francis in Cancer Biology & Therapy

Vol. 5 (1) , 65-70
DOI:10.4161/cbt.5.1.2288
PMID:16322686

Abstract

Cancer cells are characterized by epigenetic dysregulation, including global genome hypomethylation, regional hypo- and hypermethylation, altered histone modifications, and disturbed genomic imprin...

Keywords

BINDING PROTEIN
DNA METHYLATION