Coordination between transcription and pre‐mRNA processing
- 8 June 2001
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 498 (2-3) , 179-182
Abstract
A large body of work has proved that transcription by RNA polymerase II and pre‐mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy‐terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.Keywords
This publication has 47 references indexed in Scilit:
- EM Visualization of Transcription by RNA Polymerase IIMolecular Cell, 1999
- The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionNature, 1997
- The Src SH3 Domain Is Required for DNA Synthesis Induced by Platelet-derived Growth Factor and Epidermal Growth FactorJournal of Biological Chemistry, 1996
- Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription.Journal of Cell Biology, 1996
- Subunits of Yeast RNA Polymerase II Transcription Factor TFIIH Encoded by the CCL1 GeneJournal of Biological Chemistry, 1996
- Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongationNature, 1994
- Positive patches and negative noodles: linking RNA processing to transcription?Trends in Biochemical Sciences, 1993
- Higher Level Organization of Individual Gene Transcription and RNA SplicingScience, 1993
- In vitro polyadenylation is stimulated by the presence of an upstream intron.Genes & Development, 1990
- How RNA polymerase II terminates transcription in higher eukaryotesTrends in Biochemical Sciences, 1989