Dextran‐Coated Ultrasmall Gd 2 O 3 Nanoparticles as Potential T 1 MRI Contrast Agent
- 16 November 2016
- journal article
- research article
- Published by Wiley in ChemistrySelect
- Vol. 1 (19) , 6086-6091
Abstract
Ultrasmall gadolinium oxide (Gd 2 O 3 ) nanoparticles coated with dextran ( r =1500 amu) were prepared through one‐pot synthesis and their potential to act as a T 1 MRI contrast agent was investigated. The dextran‐coated ultrasmall Gd 2 O 3 nanoparticles were highly water‐dispersible, with an average particle diameter of 1.5 nm and an average hydrodynamic diameter of 12.4 nm, and non‐toxic, as determined in a cellular cytotoxicity test. The longitudinal (r 1 ) and transverse (r 2 ) water proton relaxivities were estimated to be 12.2 and 29.3 s −1 mM −1 (r 2 /r 1 =2.4), respectively, larger than those of commercial Gd‐chelates. This r 1 value is also greater than those for previously reported dextran‐coated large Gd 2 O 3 nanoparticles with particle diameter bigger than 20 nm. Positive contrast magnetic resonance (MR) images were obtained after intravenous injection of a sample solution into a mouse tail, demonstrating the potential of dextran‐coated ultrasmall Gd 2 O 3 nanoparticles as a T 1 MRI contrast agent.Keywords
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