Heterolignans: Stereoselective Synthesis of an 11‐Amino Analog of Azaelliptitoxin
Authors:
- 13 November 2008
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2008 (34) , 5687-5691
Abstract
The 11‐amino‐azaelliptitoxin analog (11R,11aS,5R)‐15 has been prepared stereoselectively in eight steps and 24 % overall yield from commercially available (S)‐glycidol (7) via the original enantiopure chiral α‐amino aldehyde 9, used as chiral precursor for the creation of the two other stereogenic centers of the target framework. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)Keywords
This publication has 44 references indexed in Scilit:
- The intermolecular Pictet-Spengler condensation with chiral carbonyl derivatives in the stereoselective syntheses of optically-active isoquinoline and indole alkaloidsArkivoc, 2005
- Synthesis and crystal structure of (R, 4R)-3-[(N-benzyl-N-hydroxy-amino)-(1H-indol-3-yl)-methyl]-oxazolidin-2-oneComptes Rendus. Chimie, 2004
- Lignans and neolignans as lead compoundsPhytochemistry Reviews, 2003
- Different strategies for the chemical synthesis of lignansPhytochemistry Reviews, 2003
- Antitumor Properties of Podophyllotoxin and Related CompoundsCurrent Pharmaceutical Design, 2000
- Nomenclature of Lignans and Neolignans (IUPAC Recommendations 2000)Pure and Applied Chemistry, 2000
- Lignans, neolignans and related compoundsNatural Product Reports, 1999
- Lignans, neolignans, and related compoundsNatural Product Reports, 1995
- Synthesis of Podophyllotoxin and Related CompoundsSynthesis, 1992
- Lignans, neolignans, and related compoundsNatural Product Reports, 1990