Advances in the Management of Lung Cancer Brain Metastases
Open Access
Abstract
Lung cancer, both non-small cell and small cell, harbors a high propensity for spreading to the central nervous system. Radiation therapy remains the backbone of the management of brain metastases. Recent advances in stereotactic radiosurgery have expanded its indications and ongoing studies seek to elucidate optimal fractionation and coordination with systemic therapies, especially targeted inhibitors with intracranial efficacy. Efforts in whole-brain radiotherapy aim to preserve neurocognition and to investigate the need for prophylactic cranial irradiation. As novel combinatorial strategies are tested and prognostic/predictive biomarkers are identified and tested, the management of brain metastases in lung cancer will become increasingly personalized to optimally balance intracranial efficacy with preserving neurocognitive function and patient values.Keywords
Funding Information
- Druckenmiller Foundation
- Society of Memorial Sloan Kettering Cancer Center
- Congressionally Directed Medical Research Programs (CDMRP)
- Delfi Diagnostics
- Caris Life Sciences
- Harbinger Health
- Varian
- DxCover
- Genece Health
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