Visualizing insulin vesicle neighborhoods in β cells by cryo–electron tomography
Open Access
- 11 December 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 6 (50) , eabc8258
Abstract
Multiple distinct tomograms of a single β cell enable investigation of the architecture of insulin vesicle neighborhoods.Keywords
Funding Information
- National Institute of General Medical Sciences (R35GM122588)
This publication has 47 references indexed in Scilit:
- Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretionDiabetologia, 2010
- Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylationIslets, 2009
- Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in miceProceedings of the National Academy of Sciences, 2009
- An Improved Cryogen for Plunge FreezingMicroscopy and Microanalysis, 2008
- Expedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic isletsJournal of Structural Biology, 2008
- Automated electron microscope tomography using robust prediction of specimen movementsJournal of Structural Biology, 2005
- Zinc–Ligand Interactions Modulate Assembly and Stability of the Insulin Hexamer – A ReviewBioMetals, 2005
- Automated molecular microscopy: The new Leginon systemJournal of Structural Biology, 2005
- Golgi Structure in Three Dimensions: Functional Insights from the Normal Rat Kidney CellJournal of Cell Biology, 1999
- Computer Visualization of Three-Dimensional Image Data Using IMODJournal of Structural Biology, 1996