Controlled Trial of Sulpiride in Chronic Schizophrenic Patients
Authors:
- J. Guy EdwardsJEJ. Guy Edwards
- John R. AlexanderJAJohn R. Alexander
- M. S. AlexanderMAM. S. Alexander
- Alan GordonAGAlan Gordon
- T. ZutchiTZT. Zutchi
- 1 December 1980
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 137 (6) , 522-529
Abstract
Summary: In a double-blind comparative trial of sulpiride (600–1,800 mg/day) and trifluoperazine (15–45 mg/day) in 38 chronic schizophrenic patients, ratings of therapeutic results and unwanted effects were made at two-weekly interviews during the six weeks treatment period. The results show that sulpiride has neuroleptic properties and a spectrum of therapeutic activity similar to that of trifluoperazine. There was an association between plasma sulpiride levels and therapeutic response after four weeks' treatment.Keywords
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