Evaluation of the direct injection nebulizer in the coupling of high-performance liquid chromatography to inductively coupled plasma mass spectrometry

Authors:
  • GZGrace Zoorob
    Grace Zoorob
  • MTMedha Tomlinson
    Medha Tomlinson
  • JWJianshang Wang
    Jianshang Wang
  • JCJoseph Caruso
    Joseph Caruso
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Abstract
A direct injection nebulizer (DIN) was designed and constructed. It was used in coupling high-performance liquid chromatography to inductively coupled plasma mass spectrometry for the speciation of chromium. Speciation of chromium using a concentric nebulizer and the DIN was investigated. Using a slight modification in the chromatographic conditions, the speciation of chromium was achieved on a microbore column. The absolute detection limit for both CrIII and CrVI was 3 pg. The DIN was used to run the National Institute of Standards and Technology Standard Reference Material (SRM) 2670 Toxic Metals in Freeze-Dried Urine, Elevated Level.