ThYme: a database for thioester-active enzymes

Authors:

Open Access

2 November 2010

journal article
research article
Published by Oxford University Press (OUP) in Nucleic Acids Research

Vol. 39 (Database) , D342-D346
DOI:10.1093/nar/gkq1072
PMID:21045059
PMCID:PMC3013676

Abstract

The ThYme (Thioester-active enzYme; http://www.enzyme.cbirc.iastate.edu ) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all the enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. These enzymes are active on thioester-containing substrates, specifically those that are parts of the acyl-CoA synthase, acyl-CoA carboxylase, acyl transferase, ketoacyl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme groups. These groups have been classified into families, members of which are similar in sequences, tertiary structures and catalytic mechanisms, implying common protein ancestry. ThYme is continually updated as sequences and tertiary structures become available.

Keywords

THYME

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