Side-Chain-Anchored Nα-Fmoc-Tyr-OPfp for Bidirectional Solid-Phase Synthesis
- 1 April 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (9) , 1703-1706
Abstract
A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With Nα-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids of spider- and wasp-type polyamine toxins using solid-phase peptide synthesis conditions.Keywords
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