Ribosomal Synthesis of Cyclic Peptides with a Fluorogenic Oxidative Coupling Reaction
Authors:
- 9 June 2009
- journal article
- research article
- Published by Wiley in ChemBioChem
- Vol. 10 (9) , 1469-1472
Abstract
Ring around the peptides: We demonstrate a new method for the cyclization of peptides that involves the oxidative coupling of 5‐hydroxyindole and benzylamine. After two nonproteinogenic amino acids were incorporated into peptides by reprogramming the genetic code, cyclization took place rapidly upon the addition of K3Fe(CN)6 and generated a conjugated, fluorescent, heterocyclic structure. magnified imageKeywords
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