Posttranslational modification of mammalian AP endonuclease (APE1)
Authors:
- 14 August 2010
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 67 (21) , 3609-3620
Abstract
A key issue in studying mammalian DNA base excision repair is how its component proteins respond to a plethora of cell-signaling mediators invoked by DNA damage and stress-inducing agents such as reactive oxygen species, and how the actions of individual BER proteins are attributed to cell survival or apoptotic/necrotic death. This article reviews the past and recent progress on posttranslational modification (PTM) of mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1).Keywords
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