The Human Cell Atlas from a cell census to a unified foundation model
Top Cited Papers
- 20 November 2024
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 637 (8048) , 1065-1071
Abstract
With the convergence in exciting advances in molecular and spatial profiling methods and new computational approaches leveraging artificial intelligence and machine learning (AI/ML), the construction of cell atlases is progressing from data collection to atlas integration and beyond. Here, we explore five ways in which cell atlases, including the Human Cell Atlas, are already revealing valuable biological insights, and how they are poised to provide even greater benefits in the coming years. In particular, we discuss cell atlases as censuses of cells; as 3D maps of cells in the body, across modalities and scales; as maps connecting genotype causes to phenotype effects; as 4D maps of development; and, ultimately, as foundation models of biology unifying all these aspects and helping to transform medicine.Keywords
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