Synthesis and anti-hepatitis B activity of new substituted uracil and thiouracil glycosides
- 1 June 2010
- journal article
- Published by Springer Nature in Archives of Pharmacal Research
- Vol. 33 (6) , 797-805
Abstract
A number of N- and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with the corresponding acetobromosugar. The synthesized compounds were tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high antiviral activities.Keywords
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