Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
Open Access
- 3 February 2010
- Vol. 15 (2) , 766-779
Abstract
Some 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole derivatives were synthesized in six steps starting from easily accessible gallic acid. The resulting sulfides were then catalytically oxidized to the title sulfones with H2O2. The products were obtained in high yield under mild conditions and practically devoid of any by-products. The structures were confirmed by elemental analysis, IR, 1H- and 13C-NMR spectral data. Furthermore, a detailed X-ray crystallography structural analysis of model triazole 7g was carried out.Keywords
This publication has 25 references indexed in Scilit:
- Synthesis, antifungal activity and CoMFA analysis of novel 1,2,4-triazolo[1,5-a]pyrimidine derivativesEuropean Journal of Medicinal Chemistry, 2008
- Synthesis and crystal structure of novel schiff bases derived from 3‐(2‐ethoxyphenyl)‐4‐amino‐5‐mercapto‐4H‐1,2,4‐triazoleJournal of Heterocyclic Chemistry, 2007
- Synthesis, structure, and bioactivity of N′-substituted benzylidene-3,4,5-trimethoxybenzohydrazide and 3-acetyl-2-substituted phenyl-5-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1,3,4-oxadiazole derivativesBioorganic & Medicinal Chemistry Letters, 2006
- Indium Trichloride‐Mediated Facile Synthesis of 3‐(Substituted methylthio)‐4‐phenyl‐5‐(3,4,5‐trimethoxyphenyl)‐4H‐1,2,4‐triazole in Water†Chinese Journal of Chemistry, 2006
- Synthesis and antibacterial activity of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)onesBioorganic & Medicinal Chemistry Letters, 2005
- Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivativesIl Farmaco, 2004
- Mechanism of Hydrogen Sulfide Oxidation by Manganese(IV) Oxide in Aqueous SolutionsLangmuir, 2003
- Phenyl Vinyl Sulfone and Sulfoxide2003
- Synthesis, Characterization, and Evaluation of Antimicrobial Activity of Some 1,2,4-Triazole Derivatives Bearing an Antipyryl MoietyMonatshefte für Chemie - Chemical Monthly, 2003
- 1,3-DithietaneJournal of the American Chemical Society, 1976