Organocatalytic enantioselective indole alkylations of α,β-unsaturated ketones
Authors:
- 19 January 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 5 (5) , 816-821
Abstract
The C3-selective enantioselective Michael-type Friedel–Crafts alkylations of indoles with nonchelating α,β-unsaturated alkyl ketones, catalysed by a chiral primary amine derived from natural cinchonine, were investigated. The reactions, in the presence of 30 mol% catalyst, were smoothly conducted at 0 to −20 °C. Moderate to good ee (47–89%) has been achieved.Keywords
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