A Chemoenzymatic Total Synthesis of the Neurogenic Starfish Ganglioside LLG‐3 Using an Engineered and Evolved Synthase
Authors:
- 23 July 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 51 (34) , 8640-8643
Abstract
An LLG-3 oligosaccharide–fluoride (see scheme) can be assembled chemoenzymatically and readily coupled with various sphingosines by an engineered endoglycoceramidase glycosynthase. The lyso ganglioside products are acylated to generate the individual isomers identified in the heterogeneous natural isolates, as well as modified glycosphingolipids.Keywords
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