Origin of thymic and peritoneal Ly‐1 B cells

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Abstract
Murine Ly‐1 B cells were first found in the peritoneal cavity (Per C). It has been thought that Ly‐1 B cells are responsible for the development of autoimmune diseases, since they spontaneously produce autoantibodies. However, we have found that such Ly‐1 B cells are present in the thymus of normal mice, and that they play a crucial role in negative selection in the Mls system. In addition, thymic Ly‐1 B cells and Per C Ly‐1 B cells have been found to differ in function, ontogeny and location. In this communication, we report on the different origins of these cells. C57BL/6 mice are lethally irradiated and reconstituted with fetal (day 14) liver cells or bone marrow cells from 4‐, 6‐ or 12‐week‐old mice. Fetal liver cells are shown to have the capacity to reconstitute both thymic and Per C Ly‐1 B cells, whereas bone marrow cells from 6‐ or 12‐week‐old mice have the capacity to reconstitute thymic Ly‐1 B cells, but not Per C Ly‐1 B cells, indicating that fetal hemopoietic stem cells (HSC) differ from HSC in the bone marrow of adult mice, and that thymic and Per C Ly‐1 B cells have different origins.

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