Effect of cerebral ischemia and hypercapnia on cerebral pH studied with 31P-NMR and electrical activity in rat brain.
Authors:
- Yoshiaki TakanashiYTYoshiaki Takanashi
- Takao MotonagaTMTakao Motonaga
- Shod NaruseSNShod Naruse
- Hiroyasu NishikawaHNHiroyasu Nishikawa
- Kimiyoshi HirakawaKHKimiyoshi Hirakawa
- 1 January 1989
- journal article
- research article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 39 (1) , 155-167
Abstract
The activity of electroencephalogram (EEG) and cortical somatosensory evoked potential (SEP) was suppressed during cerebral ischemia in rats subjected to the 4-vessel occlusion. Considerable variations were demonstrated in the decrease of phosphocreatine and ATP concentration during ischemia among the rats measured with 31P-NMR, accompanied with cerebral acidification. Hypercapnia, induced in the rats studied by the inhalation of a gas mixture of 30-40% CO2, suppressed the activity of EEG and cortical SEP. The cerebral acidification observed during the ischemia was more severe than that under the hypercapnia, implying that cerebral acidification is one of the possible causes for the decrease in the electrical activity of the brain during ischemia.Keywords
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