No Effect of Exercise on Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein 3 in Postmenopausal Women: a 12-Month Randomized Clinical Trial

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Abstract
The study was a randomized clinical trial comparing the effect of a 12-month moderate-intensity aerobic exercise intervention versus stretching control program on hormones and body composition measured at baseline, 3 months, and 12 months (5). All study procedures, including written informed consent, were reviewed and approved by the Fred Hutchinson Cancer Research Center Institutional Review Board. Participants were women, ages 50 to 75 years, sedentary, with a body mass index ≥25.0 kg/m2 (or a body mass index between 24.0 and 25.0 kg/m2 if percent body fat measured by bioelectrical impedance was greater than 33.0%), not taking hormone therapy in any form in the past 6 months, and healthy. We randomly assigned women to an exercise intervention (n = 87) or a control group (n = 86).