A combination of chlorambucil, vinblastine, procarbazine and prednisolone for treatment of Hodgkin's disease

Authors:
  • TMT J McElwain
    T J McElwain
  • JTJ Toy
    J Toy
  • ESE Smith
    E Smith
  • MPM J Peckham
    M J Peckham
  • DAD E Austin
    D E Austin

Abstract
Seventy patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (Ch1VPP). The complete remission rate of 75-7% compares well with that produced by other combinations. The combination is non-toxic, easily administered and can be given safely to outpatients. Its main advantage is that it is far less upsetting to patients than combinations containing nitrogen mustard.