Assessment of quality of life with the multiple system atrophy health‐related quality of life scale

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Abstract
Background: Multiple system atrophy (MSA) has considerable effect on health‐related quality of life (Hr‐QoL). The aim of this study was to prospectively evaluate Hr‐QoL by using the MSA health‐related Quality of Life (MSA‐QoL) scale.Methods: Evaluation of 100 patients at baseline and after a mean follow‐up of 11.5 months was performed. Assessment was made of potential associations with established markers of disease progression. Calculation was performed of sample‐size estimates for various effect sizes.Results: MSA‐QoL scale scores were less responsive to change than Unified MSA Rating Scale (UMSARS) scores. Responsiveness was largely improved and reasonable sample‐size estimates were obtained when limiting the analysis to items with significant change over time.Conclusions: The UMSARS remains the “gold standard” for disease‐modifying/neuroprotection trials. An MSA‐QoL Change Scale, based on the most responsive items, may become a valuable tool. © 2012 Movement Disorder Society

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