Antibody to signal recognition particle in polymyositis

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Using immunoprecipitation, we identified 13 patients with antibodies to the signal recognition particle (SRP) from a collection of sera representing 265 poly‐myositis/dermatomyositis (PM/DM) patients. Antibody reactivity with SRP was confirmed by enzyme‐linked immunosorbent assay and immunoprecipitation with isolated dog pancreas SRP. The antibody was present in the serum of 4% of PM/DM patients, and 18% of PM/ DM patients with anticytoplasmic antibodies other than anti‐Jo‐1, but not in patients with other conditions who had anticytoplasmic antibodies. Anti‐SRP was associated with classic adult PM, and some of these cases were unusually severe and/or of rapid onset; it was not found in patients with overlap syndromes or with DM involvement. Unlike patients with antibodies to aminoacyl‐transfer RNA synthetases, patients with anti‐SRP had a low frequency of pulmonary fibrosis, as well as of arthritis and Raynaud's phenomenon. Anti‐SRP antibodies may serve as a marker for a second, distinct subgroup of adult PM.

This publication has 53 references indexed in Scilit: