Prostaglandin Receptor Site: Evidence for an Essential Role in the Action of Luteinizing Hormone
Authors:
- 28 August 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3948) , 883-886
Abstract
A dose-response relation was established between prostaglandins and formation of adenosine 3′,5′-monophosphate in the mouse ovary. The prostaglandin antagonist, 7-oxa-13-prostynoic acid, blocked the stimulatory effect of prostaglandin E 1 , prostaglandin E 2 , and luteinizing hormone on adenosine 3′,5′-monophosphate formation in a competitive manner. Kinetic studies made it possible to suggest that there is a single luteinizing-hormone-related prostaglandin receptor in mouse ovaries, and that activation of this prostaglandin receptor is an essential requirement in the action of luteinizing hormone to stimulate adenosine 3′,5′-monophosphate formation and steroidogenesis.Keywords
This publication has 12 references indexed in Scilit:
- Prostaglandin Stimulation ofin VitroProgesterone SynthesisThe Journal of Clinical Endocrinology & Metabolism, 1970
- Inactivation of Prostaglandins by the LungsNature, 1970
- A new assay for measuring adenyl cyclase activity in intact cellsAnalytical Biochemistry, 1969
- Prostaglandin Antagonists: Synthesis and Smooth Muscle ActivityNature, 1969
- Prostaglandin Stimulation of Rat CorticosteroidogenesisScience, 1969
- Hypotheses on physiological roles of prostaglandins.Physiological Reviews, 1969
- Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′,5′-monophosphate, and theophyllineJournal of Clinical Investigation, 1968
- Effect of Prostaglandin (PGEI) on the Permeability Response of Toad Bladder to Vasopressin, Theophylline and Adenosine 3′,5′-monophosphateNature, 1965
- Effects of the Prostaglandins on Hormone-induced Mobilization of Free Fatty Acids *Journal of Clinical Investigation, 1964
- Diarsyls. VII. 4,4″-Dihydroxy- and 3,3',3″,3'″-Tetra-(hydroxyphenyl)-diarsyl. Reaction between 4-Hydroxy- and 4-Aminophenylarsine and Tetraphenylarsyl Oxide1Journal of the American Chemical Society, 1934