Blocking the ART2.2/P2X7‐system is essential to avoid a detrimental bias in functional CD4 T cell studies
- 23 March 2018
- journal article
- editorial
- Published by Wiley in European Journal of Immunology
- Vol. 48 (6) , 1078-1081
Abstract
Murine T cell subsets differ in their expression level of P2X7. Depending on several parameters like extracellular NAD+ , P2X7 can be ADP-ribosylated rapidly by adjacent ARTC2.2 resulting in susceptibilities to apoptosis to a varying extent. This detrimental effect can be prevented when drugs like KN-62 are present during cell preparations.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (BE1886/5‐1)
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