New method of linking tryptophan to cysteine sulphydryl groups in peptides and proteins
Authors:
- W. E. SavigeWSW. E. Savige
- A. FontanaAFA. Fontana
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 600-601
Abstract
A new simple method for establishing a crosslink between tryptophan and cysteine leading to tryptathionine (1), involving the reaction of 3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid (2) with cysteine in 25% trifluoroacetic acid, is described.Keywords
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