Improvements in micelle promoted DNA-encoded library synthesis by surfactant optimisation
Open Access
- 13 June 2025
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
Abstract
A principal components map was used to optimise on-DNA Suzuki–Miyaura coupling, reductive amination and reverse amide coupling reactions.Keywords
Funding Information
- Engineering and Physical Sciences Research Council (EP/S022791/1)
- Cancer Research UK (DRCDDRPGMApr2020\100002)
This publication has 26 references indexed in Scilit:
- Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged HeterocyclesJournal of the American Chemical Society, 2019
- DNA-encoded chemistry: enabling the deeper sampling of chemical spaceNature Reviews Drug Discovery, 2016
- Thermo-reversible capture and release of DNA by zwitterionic surfactantsSoft Matter, 2016
- What is a “DNA-Compatible” Reaction?ACS Combinatorial Science, 2016
- Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tagsArtificial DNA: PNA & XNA, 2014
- TPGS-750-M: A Second-Generation Amphiphile for Metal-Catalyzed Cross-Couplings in Water at Room TemperatureThe Journal of Organic Chemistry, 2011
- Interaction between DNA and Cationic Surfactants: Effect of DNA Conformation and Surfactant HeadgroupThe Journal of Physical Chemistry B, 2008
- Interaction of cationic surfactants with DNA: a single-molecule studyNucleic Acids Research, 2008
- DNA Condensation and Interaction with Zwitterionic Phospholipids Mediated by Divalent CationsLangmuir, 2006
- Encoded combinatorial chemistry.Proceedings of the National Academy of Sciences, 1992