Palytoxin evokes reversible spreading depolarization in the locust CNS

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Abstract
Spreading depolarization (SD) is a critical mechanism underlying central nervous system (CNS) shutdown and injury under stress, yet the initiating ion channel remains unknown. Here, we used the marine poison palytoxin (PLTX), which converts the sodium-potassium ATPase (NKA) into an open channel, to initiate SD in intact locust CNS. We show for the first time that PLTX-induced SD is rapid and recoverable in vivo, providing support that NKA conversion to a channel may be the SD-initiating mechanism.
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  • Canadian Government | Natural Sciences and Engineering Research Council of Canada
  • Canadian Government | Natural Sciences and Engineering Research Council of Canada

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